Atopic dermatitis, strict definition

ATOPIC_STRICT

atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 L20.0

Hospital discharge: ICD-9 6918B

Hospital discharge: ICD-8 69100

Cause of death: ICD-10 L20.0

Cause of death: ICD-9 6918B

Cause of death: ICD-8 69100

8144

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

8144

Check minimum number of events None

8144

Include endpoints None

8144

ATOPIC_STRICT

Extra metadata

First used in FinnGen datafreeze DF3

Parent code in ICD-10 L20

Name in latin Eczema atopicum

Similar endpoints

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List of similar endpoints to Atopic dermatitis, strict definition based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	7895	5515	2380
Unadjusted prevalence (%)	2.56	3.18	1.76
Mean age at first event (years)	26.40	26.72	25.66

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.93 [1.37, 2.72]	1.6e-4	164
15 years	0.01	1.30 [0.91, 1.87]	1.5e-1	75
5 years	0.00	2.36 [1.52, 3.65]	1.3e-4	36
1 year	0.00	4.20 [2.23, 7.92]	9.3e-6	12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ATOPIC_STRICT – Atopic dermatitis, strict definition
GWS hits: 25

Survival analyses between endpoints

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Plot

before Atopic dermatitis, strict definition
after Atopic dermatitis, strict definition

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Table

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Drugs most likely to be purchased after Atopic dermatitis, strict definition

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