Background retinopathy and retinal vascular changes

H7_BCKRNDRETINOPAT

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 H35.0
Hospital discharge: ICD-9 3621|3624A
Hospital discharge: ICD-8 36701|37705|37709|37712
Cause of death: ICD-10 H35.0
Cause of death: ICD-9 3621|3624A
Cause of death: ICD-8 36701|37705|37709|37712

436

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

436

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Check minimum number of events None

436

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Include endpoints None

436

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H7_BCKRNDRETINOPAT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6
Parent code in ICD-10 H35
Name in latin Retinopathia recessualis et commutationes vasculares retinae

Summary Statistics

Key figures

All Female Male
Number of individuals 416 194 222
Unadjusted prevalence (%) 0.13 0.11 0.16
Mean age at first event (years) 54.89 55.72 54.17

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.89 [1.41, 5.95] 3.9e-3 63
15 years 0.01 1.59 [0.70, 3.62] 2.7e-1 29
5 years 0.00 3.55 [1.77, 7.12] 3.7e-4 20
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_BCKRNDRETINOPAT – Background retinopathy and retinal vascular changes
GWS hits: 1

Survival analyses between endpoints

Plot

before Background retinopathy and retinal vascular changes
after Background retinopathy and retinal vascular changes

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Background retinopathy and retinal vascular changes