Hodgkin lymphoma

CD2_HODGKIN_LYMPHOMA

non-Hodgkins lymphoma: Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 C81

Hospital discharge: ICD-9 201

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 C81

Cause of death: ICD-9 201

Cause of death: ICD-8 $!$

646

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

609

Check minimum number of events None

609

Include endpoints None

609

CD2_HODGKIN_LYMPHOMA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF4

Parent code in ICD-10 C81-C96

Name in latin Morbus Hodgkin

Similar endpoints

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List of similar endpoints to Hodgkin lymphoma based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	586	286	300
Unadjusted prevalence (%)	0.19	0.16	0.22
Mean age at first event (years)	47.12	41.82	52.17

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.61 [1.44, 4.71]	1.5e-3	82
15 years	0.01	1.29 [0.65, 2.58]	4.6e-1	32
5 years	0.00	2.67 [1.26, 5.67]	1.0e-2	21
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CD2_HODGKIN_LYMPHOMA – Hodgkin lymphoma
GWS hits: 0

Survival analyses between endpoints

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Plot

before Hodgkin lymphoma
after Hodgkin lymphoma

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Table

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Drugs most likely to be purchased after Hodgkin lymphoma

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