Malignant neoplasm of liver and intrahepatic bile ducts

C3_LIVER_INTRAHEPATIC_BILE_DUCTS

liver neoplasm: A benign or malignant epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts. Representative examples of benign epithelial neoplasms include hepatocellular adenoma and intrahepatic bile duct adenoma. Representative examples of malignant epithelial neoplasms include hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Cause of death: ICD-10 C22

Cause of death: ICD-9 155

Cause of death: ICD-8 155

Cancer registry: Topography ICD-O-3 C22

541

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

541

Check minimum number of events None

541

Include endpoints None

541

C3_LIVER_INTRAHEPATIC_BILE_DUCTS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF4

Similar endpoints

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List of similar endpoints to Malignant neoplasm of liver and intrahepatic bile ducts based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

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Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	518	101	417
Unadjusted prevalence (%)	0.17	0.06	0.31
Mean age at first event (years)	70.50	68.04	71.10

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_LIVER_INTRAHEPATIC_BILE_DUCTS – Malignant neoplasm of liver and intrahepatic bile ducts
GWS hits: 2

Survival analyses between endpoints

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Plot

before Malignant neoplasm of liver and intrahepatic bile ducts
after Malignant neoplasm of liver and intrahepatic bile ducts

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Table

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Drugs most likely to be purchased after Malignant neoplasm of liver and intrahepatic bile ducts

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