Seropositive rheumatoid arthritis, strict definition

RHEUMA_SEROPOS_STRICT

Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions

RHEUMA_SEROPOS_OTH_ICD10

7209

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Filter registries

KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 M05

6784

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Check pre-conditions, main-only, mode, ICD version None

3364

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Check minimum number of events None

3364

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Include endpoints None

3364

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RHEUMA_SEROPOS_STRICT

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 3277 2310 967
Unadjusted prevalence (%) 1.06 1.33 0.72
Mean age at first event (years) 56.00 54.49 59.60

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.25 [0.78, 2.01] 3.5e-1 136
15 years 0.01 0.92 [0.61, 1.40] 7.0e-1 75
5 years 0.00 1.26 [0.79, 1.99] 3.3e-1 30
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: RHEUMA_SEROPOS_STRICT – Seropositive rheumatoid arthritis, strict definition
GWS hits: 8

Survival analyses between endpoints

Plot

before Seropositive rheumatoid arthritis, strict definition
after Seropositive rheumatoid arthritis, strict definition

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Drugs most likely to be purchased after Seropositive rheumatoid arthritis, strict definition